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Search Results for " complement c3 "
Targets Recommended: Complement System

9

抑制剂 & 化合物

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天然产物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
TP2180L Compstatin control peptide acetate

Complement System Immunology/Inflammation
Compstatin control peptide acetate 是补体蛋白 C3 的抑制剂，通过结合和抑制补体 C3 的切割。
TP2139 AMY-101

Cp40

 Others Others
AMY-101 is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.
T9695L POT-4 acetate

POT-4 acetate (934461-40-2 free base)

 Complement System Immunology/Inflammation
POT-4 acetate 抑制 Complement C3 的活化。 POT-4 acetate 可用于年龄相关性黄斑变性的研究。
T82474 Empasiprubart

ARGX-117
Empasiprubart (ARGX-117) 是一种针对补体 C2 的人源化抑制性单克隆抗体。该抗体通过结合 C2 的 Sushi-2 结构域来阻止 C3 原转化酶的形成，进而抑制 C3 的激活，并阻断经典途径与凝集素途径的上游激活。Empasiprubart 展现出 pH 和钙依赖性的靶标结合能力，并在自身免疫性溶血性贫血以及抗体介导的器官移植排斥模型中，预防了补体介导的细胞毒性作用。
TP2139L AMY-101 TFA

Cp40 TFA

 Others Others
AMY-101 TFA (Cp40 TFA) is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 TFA shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.
T75775 Compstatin TFA

Compstatin TFA是一种含有13个残基的环肽，作为补体系统C3的高效抑制剂，显示出物种特异性。该化合物能够结合到狒狒的C3上，并抵抗狒狒血液中的蛋白质水解裂解（与人类相似）。Compstatin TFA专一性地抑制灵长类动物的补体系统激活。其对补体经典途径和旁路途径的IC50值分别为63μM和12μM。
T76210 POT-4 TFA

POT-4 TFA (AL-78898A TFA)，Compstatin 衍生物，有效抑制补体因子 C3 激活，适应于年龄相关黄斑变性研究。
T64692 AMY-101 acetate

Complement component C3 plays a particularly versatile role in this process by keeping the cascade alert, acting as a point of convergence of activation pathways, fueling the amplification of the complement response, exerting direct effector functions, and helping to coordinate downstream immune responses[3]. In C3-/- mice alcohol-induced liver steatosis is absent or strongly reduced after chronic or acute alcohol exposure. This suggests that the complement system and its component C3 contribute...
T77089 Mirococept

Mirococept (APT070) 是一种抗体，靶向补体系统 (complement system) 的 C3b/C4b，也是一种膜定位的 C3转化酶抑制剂。Mirococept 减少 C 肽和促炎细胞因子的释放，并减少炎症细胞的浸润。Mirococept 减少胰岛内炎症，有利于胰岛移植。Mirococept 还抑制增加的肠和肺血管通透性以减少中性粒细胞流入。

化合物

Compstatin control peptide acetate
Cat.No: TP2180L
Synonym:
Target: Complement System
AMY-101
Cat.No: TP2139
Synonym: Cp40
Target: Others
POT-4 acetate
Cat.No: T9695L
Synonym: POT-4 acetate (934461-40-2 free base)
Target: Complement System
Empasiprubart
Cat.No: T82474
Synonym: ARGX-117
Target:
AMY-101 TFA
Cat.No: TP2139L
Synonym: Cp40 TFA
Target: Others
Compstatin TFA
Cat.No: T75775
Synonym:
Target:
POT-4 TFA
Cat.No: T76210
Synonym:
Target:
AMY-101 acetate
Cat.No: T64692
Synonym:
Target:
Mirococept
Cat.No: T77089
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T40646 Lipoteichoic acid

Complement System Immunology/Inflammation
Lipoteichoic acid 是 Staphylococcus aureus 细胞壁的聚合物，通过诱导 C3 和抑制 CD55 来激活补体系统，通过 IGF-1 途径减少脂肪沉积。

天然产物

Lipoteichoic acid
Cat.No: T40646
Synonym:
Target: Complement System
Species：
Mouse (9)
Human (5)
Rat (3)
Cynomolgus (2)
Bovine (1)
Enterococcus faecalis (1)
Naja kaouthia (1)
Rhesus (1)
Staphylococcus aureus (1)
VACV (1)
Expression System：
HEK293 Cells (12)
E. coli (11)
Baculovirus Insect Cells (1)
P. pastoris (Yeast) (1)
Tag：
N-6xHis (6)
C-His (5)
N-6xHis-SUMO (5)
C-6xHis (3)
N-10xHis, C-Myc (3)
C-hFc (2)
C-mFc (1)
Cat. No. Product Name Species Expression System
TMPH-02604 Complement C3 Protein, Mouse, Recombinant (His & SUMO)

C3,Complement C3

 Mouse E. coli
Complement C3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.3 kDa and the accession number is P01027.
TMPY-05732 Complement C3 Protein, Cynomolgus, Recombinant (His)

complement component 3

 Cynomolgus HEK293 Cells
Complement C3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 186.40 kDa and the accession number is XP_005587776.1.
TMPH-00231 Complement C3 Protein, Bovine, Recombinant (His & SUMO)

Complement C3,C3

 Bovine E. coli
Complement C3 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 39.5 kDa and the accession number is Q2UVX4.
TMPY-05731 Complement C3 Protein, Human, Recombinant (His)

HEL-S-62p,CPAMD1,ARMD9,C3b,ASP,C3a,AHUS5,<...

 Human HEK293 Cells
Complement C3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 186.43 kDa and the accession number is P01024.
TMPY-06767 Complement C3 Protein, Mouse, Recombinant (His)

HSE-MSF,complement component 3,Plp,AI255234,ASP

 Mouse HEK293 Cells
Complement C3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.34 kDa and the accession number is NP_033908.2.
TMPK-01268 Complement C2 Protein, Cynomolgus, Recombinant (His)

C2,CO2,Complement C2,C3/C5 convertase,ARMD...

 Cynomolgus HEK293 Cells
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to healthy controls, and C2 was associated with TNM stages. Higher C2 expression was significantly associated with better prognosis, and multivariate analysis showed that C2 was also an independent factor for the prognosis of HCC.
TMPH-03038 Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)

Cobra venom factor,Complement C3 homolog,C...

 Naja kaouthia E. coli
Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re...
TMPJ-00149 Complement Factor D/CFD Protein, Mouse, Recombinant (His)

C3 convertase activator,28 kDa adipocyte protein,Cf...

 Mouse HEK293 Cells
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the...
TMPH-02607 Complement factor B Protein, Mouse, Recombinant (His)

C3/C5 convertase,Complement factor B,Cfb,B...

 Mouse E. coli
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.
TMPH-02605 Complement C4-B Protein, Mouse, Recombinant (His)

C3 and PZP-like alpha-2-macroglobulin domain-contai...

 Mouse E. coli
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
TMPH-01131 Complement C4-B Protein, Human, Recombinant (His & SUMO)

C4B,C3 and PZP-like alpha-2-macroglobulin domain-co...

 Human E. coli
Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPK-00671 Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)

Adipsin,CFD,ADN,Complement factor D,DF,AMBP-1,EC 3....

 Rhesus HEK293 Cells
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Rhesus macaq...
TMPK-00755 Complement Factor D/CFD Protein, Human, Recombinant (hFc)

C3 convertase activator,DF,AMBP-1,EC 3.4.21,EC 3.4....

 Human HEK293 Cells
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Human, Recom...
TMPH-03272 Complement factor D Protein, Rat, Recombinant (His)

Adipsin,Df,Adn,C3 convertase activator,Compleme...

 Rat P. pastoris (Yeast)
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
TMPH-03271 Complement factor D Protein, Rat, Recombinant (His & Myc)

Adn,C3 convertase activator,Properdin factor D,...

 Rat HEK293 Cells
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is P32038.
TMPK-00151 Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)

C3 convertase activator,AMBP-1,PFD,FACTOR D,CFD,ADN...

 Mouse HEK293 Cells
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Mouse, Recom...
TMPH-02845 Properdin Protein, Mouse, Recombinant (His & Myc)

Mouse HEK293 Cells
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
TMPH-02844 Properdin Protein, Mouse, Recombinant (His)

Mouse E. coli
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
TMPH-02921 SUSD4 Protein, Mouse, Recombinant (His)

Mouse E. coli
Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. SUSD4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.5 kDa and the accession number is Q8BH32.
TMPH-03326 MASP2 Protein, Rat, Recombinant (His)

Rat Baculovirus Insect Cells
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. MASP2 Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 79.2 kDa and the accession number is Q9JJS8.
TMPH-03665 Vaccinia virus (strain Copenhagen) OPG185 Protein (His)

VACV E. coli
Prevents cell to cell fusion by interacting with and directing the viral K2 protein on the host plasma membrane. The A56-K2 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation. Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack. Vaccinia virus (strain Copenhagen) OPG185 Protein (His) is expressed in E. coli expression system with ...
TMPH-03578 SCIN Protein, S. aureus, Recombinant (His & Myc)

Staphylococcus aureus E. coli
Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses. SCIN Protein, S. aureus, ...
TMPJ-00809 CFH Protein, Human, Recombinant (His)

CFH,Complement factor H

 Human HEK293 Cells
Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessi...
TMPY-03969 SUSD4 Protein, Human, Recombinant (mFc)

sushi domain containing 4,PRO222

 Human HEK293 Cells
SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and testis but not other tissues. In brains, SUSD4 is highly expressed in the white matter on oligodendrocytes/axons, and in eyes, it is exclusively expressed on the photoreceptor outer segments. In in vitro complement assays, SUSD4 augments the alternative but not the classical path...
TMPH-00534 Gelatinase Protein, Enterococcus faecalis, Recombinant (His & SUMO)

Enterococcus faecalis E. coli
Metalloprotease capable of the hydrolysis of insoluble hydrophobic substrates. Hydrolyzes azocoll and gelatin and, at a lower rate, soluble and insoluble collagens. Does not cleave short synthetic peptides. Preferentially hydrolyzes the 24-Phe-|-Phe-25 bond in the insulin B-chain, followed by the 5-His-|-Leu-6 bond. Inactivates endothelin-1, primarily by cleavage of the 5-Ser-|-Leu-6 and 16-His-|-Leu-17 bonds. Hydrolyzes the alpha chain of C3 to generate a C3b-like protein. Inhibits complement-m...

重组蛋白

Complement C3 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02604
Species: Mouse
Expression System: E. coli
Complement C3 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-05732
Species: Cynomolgus
Expression System: HEK293 Cells
Complement C3 Protein, Bovine, Recombinant (His & SUMO)
Cat.No: TMPH-00231
Species: Bovine
Expression System: E. coli
Complement C3 Protein, Human, Recombinant (His)
Cat.No: TMPY-05731
Species: Human
Expression System: HEK293 Cells
Complement C3 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-06767
Species: Mouse
Expression System: HEK293 Cells
Complement C2 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01268
Species: Cynomolgus
Expression System: HEK293 Cells
Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)
Cat.No: TMPH-03038
Species: Naja kaouthia
Expression System: E. coli
Complement Factor D/CFD Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00149
Species: Mouse
Expression System: HEK293 Cells
Complement factor B Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02607
Species: Mouse
Expression System: E. coli
Complement C4-B Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02605
Species: Mouse
Expression System: E. coli
Complement C4-B Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01131
Species: Human
Expression System: E. coli
Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)
Cat.No: TMPK-00671
Species: Rhesus
Expression System: HEK293 Cells
Complement Factor D/CFD Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00755
Species: Human
Expression System: HEK293 Cells
Complement factor D Protein, Rat, Recombinant (His)
Cat.No: TMPH-03272
Species: Rat
Expression System: P. pastoris (Yeast)
Complement factor D Protein, Rat, Recombinant (His & Myc)
Cat.No: TMPH-03271
Species: Rat
Expression System: HEK293 Cells
Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00151
Species: Mouse
Expression System: HEK293 Cells
Properdin Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02845
Species: Mouse
Expression System: HEK293 Cells
Properdin Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02844
Species: Mouse
Expression System: E. coli
SUSD4 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02921
Species: Mouse
Expression System: E. coli
MASP2 Protein, Rat, Recombinant (His)
Cat.No: TMPH-03326
Species: Rat
Expression System: Baculovirus Insect Cells
Vaccinia virus (strain Copenhagen) OPG185 Protein (His)
Cat.No: TMPH-03665
Species: VACV
Expression System: E. coli
SCIN Protein, S. aureus, Recombinant (His & Myc)
Cat.No: TMPH-03578
Species: Staphylococcus aureus
Expression System: E. coli
CFH Protein, Human, Recombinant (His)
Cat.No: TMPJ-00809
Species: Human
Expression System: HEK293 Cells
SUSD4 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-03969
Species: Human
Expression System: HEK293 Cells
Gelatinase Protein, Enterococcus faecalis, Recombinant (His & SUMO)
Cat.No: TMPH-00534
Species: Enterococcus faecalis
Expression System: E. coli
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